Development and effect of drug release from simvastatin loaded sodium alginate micro beads

The objective of the present study was to prepare microbeads Simvastatin loaded with sodium alginate provide control release drug delivery system. So, design system improve and enhance bioavailability drug. were prepared by ionic gelation method using polymer such as a natural substance. formulated different cross linking agent like CaCl₂, BaCl₂, ZnCl₂ FeCl₃ in ratio. spherical, free flowing exhibited content uniformity high encapsulation efficiency. swelling behavior depends upon amount used microbeads. This released up 24 hours where beads 6 hours. FTIR analysis drug, polymers optimized formulation indicated compatibility polymers. DSC studies confirmed interaction microspheres. SEM influence rate from concludes that In-vitro can be considered promising